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Program

November 5th 2017

 

13:00-14:30 REGISTRATION AND POSTER SET UP

14:30-15:00 WELCOME BY HONORARY MEMBERS AND PIERA VALENTI

PLENARY SECTION

CHAIR PERSONS: EMILIA CHIANCONE AND EUGENIO GAUDIO

CHARACTERIZATION AND CONTROL QUALITY OF LACTOFERRIN AND ITS PEPTIDES

(All the presentations include 5 min of discussion)

15:00-15:30 Bo Lonnerdal (University of California, Davis – USA): Lactoferrin, a multifunctional glycoprotein.

15:30-16:00 Hans Vogel (University of Calgary, Calgary – Canada): Structures and functions of different peptides derived from bovine and human lactoferrin.

16:00-16:30 Mamoru Tomita (Dairy Techno Inc., Japan): Perspective on lactoferrin quality for research and application.

16:30-17:00 COFFEE BREAK

CHAIR PERSONS: PIERA VALENTI AND JEAN-PAUL PERRAUDIN

17:00-17:30 Stefan Weisgerber (European Patent Attorney, Modiano & Partners, Italy, Germany, Switzerland): The Intellectual property: patents for  nutraceuticals.

17:30-18:00 Marco Silano (Istituto Superiore di Sanità, Rome – Italy): Characterization and control quality of nutraceutical substances: past, present and future.

18:00-18:30 GENERAL DISCUSSION

19:00 WELCOME PARTY

 

November 6th 2017

CHARACTERIZATION AND CONTROL QUALITY OF LACTOFERRIN AND ITS PEPTIDES

(All the presentations include 5 min of discussion)

CHAIR PERSONS: BO LÖNNERDAL AND THERESA OCHOA

09:00-09:30 Hiroyuki Wakabayashi (Morinaga Milk Industry, Japan): Quality control of lactoferrin.

09:30-10:00 Jean-Paul Perraudin (Taradon Laboratory, Belgium): Industrial purification of lactoferrin: characterization and quality control.

10:00-10:30 Mikogami Takashi (Armor Proteines, France): A cell-based antioxidant activity assay: a useful tool for quality control of bovine lactoferrin ingredients.

10:30-11:00 COFFEE BREAK

CHAIR PERSONS: HANS VOGEL AND NIDIA LEÓN SICAIROS

11:00-11:30 Audrey Boulier (Ingredia SA,  France): The Physiological efficacy of Lactoferrin is dependent upon its structural integrity.

11:30-12:00 Greg Farrant (Tatua Dairy Company, New Zealand): Experience in preserving the activity of bovine lactoferrin throughout commercial processing.

12:00–12:30 Piera Valenti (University of  Rome La Sapienza, Rome – Italy): Physico-chemical properties influence the functions and efficacy of commercial bovine lactoferrins

12:30-12:45 Rastogi Nilisha (All India Institute of Medical Sciences, New Delhi – India): Trypsin Digested Fragments of Bovine Lactoferrin and formation of their silver nanoparticles: Structural and Functional studies. AWARD

12:45–13:00 Maxim Kiryukhin (Institute of Materials Research and Engineering, Singapore): Protein – polyphenol multilayer microcapsules for oral delivery of lactoferrin.

13:00-15:00 LUNCH

LACTOFERRIN AND ITS IMMUNOMODULATING ACTIVITY

CHAIR PERSONS: GIOVANNI MUSCI AND HIROYUKI WAKABAYASHI

(All the presentations include 5 min of discussion)

15:00-15:30 Hans Vogel (University of Calgary, Calgary – Canada): Lactoferrin interactions with other proteins involved in host-defense.

15:30-15:50 Shen-An Hwang (University of Texas, Houston – USA): Recombinant Fc-human lactoferrin fusion protein as adjuvant for the BCG vaccine.

15:50-16:10 Daisy Vanrompay (Ghent University, Ghent – Belgium): Rectal administration of lactoferrin clears an Escherichia coli (EHEC) infection in cattle and lactoferrin translocates to the nucleus of rectal epithelial cells. AWARD

16:10-16:30 Francesca Berlutti  (University of Rome La Sapienza, Rome – Italy): Influence of aerosolized bovine lactoferrin in infection and inflammation processes in  cystic fibrosis mice.

16:30-17:00 COFFEE BREAK

CHAIR PERSONS: VADIM VASILYEV AND ANTIMO CUTONE

17:00-17:20 Andrea Kühnle (Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf–Germany): The formation of polySia-lactoferrin complexes supports lactoferrin to counteract the release of neutrophil extracellular traps. AWARD

17:20-17:40 Morishita Satoru (Lion Corporation, Japan): Bovine Lactoferrin Ameliorates the Development of Atopic Dermatitis-like Skin Lesions and the Production of IL-17 in Splenocytes of NC/Nga Mice.

17:40-18:00 Chiara Gramaccioni (European Synchrotron Radiation Facility, Grenoble – France; University of Rome La Sapienza, Rome – Italy): Influence of lactoferrin on intracellular iron concentration in inflamed and non-inflamed macrophages.

18:00-19:00 POSTER SECTION

 

November 7th 2017

LACTOFERRIN: IRON AND INFLAMMATORY HOMEOSTASIS

(All the presentations include 5 min of discussion)

CHAIR PERSONS: VADIM VASILYEV AND JILLIAN CORNISH

09:00-09:30 Giovanni Musci (University of Molise, Italy): Lactoferrin Efficiently Counteracts the Inflammation-Induced Changes of the Iron Homeostasis System in Macrophages.

09:30-10:00 Alexey Sokolov(Saint-Petersburg State University, Russia): Lactoferrin, ceruloplasmin and their complex modulate the functional activity of neutrophils.

10:00-10:15 Valeria Kostevich (Saint-Petersburg State University,Saint-Petersburg – Russia): Comparison of interaction between ceruloplasmin and lactoferrin/transferrin: to bind or not to bind. AWARD

10:15-10:30 Gary Gelbfish (Metrodora, New York – USA): Clinical Development of Metrodora Therapeutics’ Bovine Lactoferrin (MTbLF): Ongoing Cohort Dose-Escalation Study in Patients with Anemia and Crohn’s Disease.

10:30-11:00 COFFEE BREAK

LACTOFERRIN: CELL PROLIFERATION AND DIFFERENTIATION 

(All the presentations include 5 min of discussion)

CHAIR PERSONS: ALEXEY SOKOLOV AND JILLIAN CORNISH

11:00-11:20 Vadim Vasilyev (Saint-Petersburg State University, Saint-Petersburg – Russia): Apo-lactoferrin causes stabilization and nuclear translocation of Nrf2 along with expression of antioxidant response target genes.

LACTOFERRIN RECEPTORS AND LOCALIZATION

(All the presentations include 5 min of discussion)

CHAIR PERSONS: FRANCESCA BERLUTTI AND JIANHUA WANG

11:20-11:50 Anthony B. Schryvers (University of Calgary, Calgary – Canada): Are lactoferrin receptors viable vaccine targets?

11:50-12:20 Nicolas Ostan  (University of Toronto, Ontario – Canada): Mechanism of lactoferrin and lactoferricin sequestration by pathogenic Moraxella bovis. AWARD

13:00-15:00 LUNCH

LACTOFERRIN FUNCTIONS FROM LABORATORY SUGGESTIONS TO CONFIRMATIONS IN ANIMALS AND HUMANS: INFECTIOUS DISEASES

(All the presentations include 5 min of discussion)

CHAIR PERSONS: ANTHONY B. SCHRYVERS AND MARIA PIA CONTE

15:00-15:30 Nidia León Sicairos (University of Sinaloa, Sinaloa – Mexico): Influence of lactoferrin and its peptides against bacterial infections in mice.

15:30-16:00 Jianhua Wang (Chinese Academy of Agricultural Sciences  Beijing, Beijing – China): Enhancement of killing to Staphylococcus aureus and Salmonella pullorum and neutralization of lipopolysaccharide 17-residue bovine lactoferricins by cyclization and D-type amino acid substitution

16:00-16:15 Juhi Sikarwar (AIIMS, New Delhi): Lactoferrin as a potent inhibitor to control biofilm formation in Pseudomonas Aeruginosa and Acinetobacter baumannii. AWARD

16:15-16:30 Uriel Angulo-Zamudio (Universidad Autónoma de Sinaloa, Sinaloa, Mexico): Effect of lactoferrin-derived synthetic peptides on Salmonella enterica ATCC 14028 planktonic cells and biofilms. AWARD

16:30-17:00 COFFEE BREAK

CHAIR PERSONS: ANNA TERESA PALAMARA AND ERIC NONNECKE

17:00-17:20 Paula E. Florian (Institute of Biochemistry of the Romanian, Bucharest, Romania): Lactoferrin-derived peptides with anti- hepatitis B virus properties. AWARD 

17:20-17:40 Lourdes Sánchez (Universidad de Zaragoza, Zaragoza – Spain): Antirotaviral potential of lactoferrin from different origin: effect of thermal and high pressure treatments.

17:40-18:00 Eric Cox (Ghent University, Ghent – Belgium): The many faces of lactoferrin in the control of Escherichia coli O157 infections.

18:00-19:00 POSTER SECTION

 

November 8th 2017

09:00-13:00 FORI IMPERIALI OR GALLERIA BORGHESE

15:00-17:40 LACTOFERRIN FUNCTIONS FROM LABORATORY SUGGESTIONS TO CONFIRMATIONS IN ANIMALS AND HUMANS: GASTROENTEROLOGY

(All the presentations include 5 min of discussion)

CHAIR PERSONS: BO LÖNNERDAL AND ANNE BLAIS

15:00-15:30 Eric Nonnecke (University of California, Davis – USA):  A colitis model: investigating the effector functions of lactoferrin and the lactoferrin receptor using knock-out  mouse model.

15:30-16:00 Romina Mancinelli (University of Rome La Sapienza, Rome – Italy): Lactoferrin and its receptors on biliary epithelium.

16:00-16:30 COFFEE BREAK

BREAST MILK AND INFANT FORMULA

(All the presentations include 5 min of discussion)

CHAIR PERSONS: BO LÖNNERDAL AND ANNE BLAIS

16:30-17:00 Anne Blais, Danie Tomé (AgroParisTech, INRA, Paris – France): Lactoferrin and infant health: a multifunctional protein.

17:00-17:20 Md Abdul Wazed (University of Auckland, New Zealand): Comparative study on thermal and high pressure treatments of Lactoferrin (LF) enriched pasteurized ready-to-feed (RTF) formula.

17:20-17:40 Jaganmohan Billakanti (Callaghan Innovation, New Zealand):  Standardized Analytical Methods for Quantification of Lactoferrin in Dairy Products. AWARD

17:40-19:00 POSTER SECTION

 

November 9th 2017

LACTOFERRIN AND OBESITY

(All the presentations include 5 min of discussion)

CHAIR PERSONS: PIERA VALENTI AND HANS VOGEL

09:00-09:30 Kanae Nakamura (Lion Corporation, Kanagawa, Japan,): Lactoferrin promotes the energy expenditure via cAMP-PKA signaling pathway in reprogrammed functional brown adipocytes.

LACTOFERRIN FUNCTIONS FROM LABORATORY SUGGESTIONS TO CONFIRMATIONS IN ANIMALS AND HUMANS: NEONATOLOGY

(All the presentations include 5 min of discussion) 

CHAIR PERSONS: PIERA VALENTI AND HANS VOGEL

09:30-10:00 Paolo Manzoni (S. Anna Hospital, Torino – Italy): Oral lactoferrin for the prevention of sepsis and necrotizing enterocolitis in preterm infants.

10:00-10:30 Theresa Ochoa (Universidad Peruana Cayetano Heredia, Lima – Peru):   Long-term outcomes of infants <2000 g after neonatal lactoferrin supplementation.

10:30-11:00 COFFEE BREAK

CNS DEVELOPMENT

(All the presentations include 5 min of discussion) 

CHAIR PERSONS: PAOLO MANZONI AND ROMINA MANCINELLI

11:00 -11:30 Momoko Miyakawa (Morinaga Milk Industry Co., Ltd., Japan): The effect of lactoferrin against behavioral and transcriptional alteration induced by maternal separation in male rat. 

11:30-12:00 Takashi Takeuchi (Tottori University, Japan): Lactoferrin suppressed early life maternal separation-induced anxiety in female rat pups (F1) that developed into unfavorable emotional changes in their offspring (F2).

LACTOFERRIN FUNCTIONS FROM LABORATORY SUGGESTIONS TO CONFIRMATIONS IN ANIMALS AND HUMANS: GYNECOLOGY

(All the presentations include 5 min of discussion) 

CHAIR PERSONS: PAOLO MANZONI AND ROMINA MANCINELLI

12:00-12:30 Paola Mastromarino  (University of Rome La Sapienza, Rome – Italy): Lactoferrin and lactobacilli as actors in the scenario of cervicovaginal defense.

12:30-12:45 Simone Filardo (University of Rome La Sapienza, Rome – Italy): Lactoferrin and lactobacilli against Chlamydia trachomatis genital infections. AWARD

13:00-15:00 LUNCH

LACTOFERRIN FUNCTIONS FROM LABORATORY SUGGESTIONS TO CONFIRMATIONS IN ANIMALS AND HUMANS: BONE REGENERATION AND WOUND HEALING

(All the presentations include 5 min of discussion) 

CHAIR PERSONS: JIANHUA WANG AND MARIA PIA CONTE

15:00-15:30 Jillian Cornish (University of Auckland, Auckland – New Zealand):  Bovine Lactoferrin Promotes Bone Regeneration.

15:30-16:00 Francesco Calvani (University of Rome La Sapienza, Rome – Italy): Lactoferrin in healing the wounds in maxillo facial pathologies. AWARD 

LACTOFERRIN FUNCTIONS FROM LABORATORY SUGGESTIONS TO CONFIRMATIONS IN ANIMALS AND HUMANS: INFECTIOUS DISEASES

16:00-16:30 Victor Juarez Perez  (Alaxia Company, France): Lactoferrin, bactericidal/bacteriostatic compound? Huge need for method harmonization.

16:30-17:00 COFFEE BREAK

17:00-18:00 POSTER SECTION 

20:00 GALA DINNER

 

November 10th 2017

NOVEL USES

(All the presentations include 5 min of discussion) 

CHAIR PERSONS: MAMURU TOMITA AND DANIE TOMÈ

09:30-10:00 Jianping Wu (University of Alberta, Canada): Ovotransferrin derived tripeptide IRW shows blood pressure lowering activity in spontaneously hypertensive rat (SHR).

10:00-10:30 Laura E. Quintero-Martinez (University of Sinaloa, Sinaloa – Mexico): Bovine lactoferrin supplementation improves survival of mice with LPS-induced sepsis. AWARD

10:30-11:00 COFFEE BREAK

CHAIR PERSONS: MD ABDUL WAZED AND TAKASHI TAKEUCHI

11:00-11:30  Adalberto Castro-Arizmendi  (University of Sinaloa, Sinaloa – Mexico): Prophylactic and therapeutic effect of Lactoferrin and Lactoferrin chimera in a mouse model of intestinal Vibrio cholerae infection. AWARD

11:30- 12:00  Takahiro Moriya (Tohoku University, Japan): The potentiatiting action of bovine lactoferrin on the light entrainment of the circadian clock in mice.

12:00-12:30 AWARD

12:30-13:00 CONCLUDING REMARKS

13:00-14:00 LUNCH

ARRIVEDERCI TO….